4-[4-(Substituted)piperidino]quinazoline cardiac stimulants

Details 4-[4-(Substituted)piperidino]quinazoline cardiac stimulants 4-[4-(Substituted)piperidino]quinazoline cardiac stimulants

1978-10-26

1980-02-12

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544293, 546301, A61K 31505, C07D40104

Patent

active

041883918

ABSTRACT:
6,7-Dialkoxy-4-[4-(substituted)piperidino]quinazolines wherein the 4-substituent is -(CHR.sup.1).sub.m -Z wherein R.sup.1 is hydrogen or lower alkyl; m is 1 or 2, with the proviso that when m is 2, each R.sup.1 can be the same or different; Z is -N(R.sup.2)COR.sup.3, -OCONR.sup.4 R.sup.5, N(R.sup.2)SO.sub.2 R.sup.3 or -N(R.sup.2)CONR.sup.4 R.sup.5 wherein R.sup.2 is hydrogen or lower alkyl; R.sup.3 is lower alkyl, benzyl or phenyl; and each of R.sup.4 and R.sup.5 is hydrogen or is selected from group R.sup.3 ; and methods for their preparation. The compounds are phosphodiesterase inhibitors and cardiac stimulants.

REFERENCES:
patent: 3517005 (1970-06-01), Cronin et al.
patent: 3594480 (1971-07-01), Cronin et al.
patent: 3812127 (1974-05-01), Cronin et al.
patent: 4001422 (1977-01-01), Danilewiez et al.

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