4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-

Details 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol- 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-

1981-05-04

1982-05-11

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546194, 546197, 424267, C07D40114, C07D40106

Patent

active

043294715

ABSTRACT:
1,3-Dihydro-2H-imidazol-2-ones having 5-acyl and 4-(4-phenyl-1-piperidinyl)methyl substituents, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate substituted piperidine with a substituted 4-bromomethyl-1,3-dihydro-2H-imidazol-2-one.

REFERENCES:
patent: 2441933 (1948-05-01), Duschinsky
patent: 2514380 (1950-07-01), Duschinsky
patent: 3303199 (1967-02-01), Doebel et al.
Morrison and Boyd, "Organic Chemistry", 3rd Edition, (1973), pp. 745-746, (Allyn and Bacon).
Fed. Proc., 39:1105, (1980), (Abstract), Dage et al.
Duschinsky and Dolan, "J. Am. Chem. Soc.", vol. 68, pp. 2350-2355, (1946), vol. 70, pp. 657-662, (1948).

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