4,4-Disubstituted spiro-1,4-dihydropyridines and a process for t

Details 4,4-Disubstituted spiro-1,4-dihydropyridines and a process for t 4,4-Disubstituted spiro-1,4-dihydropyridines and a process for t

1981-06-04

1982-09-14

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 16, 544330, 544331, C07D47110, C07D47120

Patent

active

043496750

ABSTRACT:
The invention relates to 4,4-disubstituted spiro-1,4-dihydropyridine compounds of formula (I). Also included in the invention are methods for producing the compounds of formula (I) by (a) cyclizing a compound of formula (II) in the presence of a base or (b) reducing a sulphinyl compound of formula (I) by means of Raney nickel.
The compounds of formula I are intermediates and can be converted to sulphur-free compounds of formula (III) which are known to be useful for treating circulatory illnesses.

REFERENCES:
Ong et al., "J. Med. Chem.", vol. 24, No. 1, (1981), pp. 74-79.

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