4,4-disubstituted-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as

Details 4,4-disubstituted-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as 4,4-disubstituted-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as

1998-10-21

2000-10-31

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 89, C07D26518

Patent

active

061404993

ABSTRACT:
The present invention relates to benzoxazinones of formula I: ##STR1## or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, methods of using the same for treating viral infection or as an assay standard or reagent, and intermediates and processes for making the same.

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Coppola et al, J. Org. Chem. 1976, 41 (5), 825-831, "Chemistry of 2H-3, 1-Benzoxazine-2,4(1H)-dione(Isatoic Anhydride). 2.Reactions with Thiopseudoureas and Carbanions."
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