4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

544 89, 544 92, 5142305, A61K 31535, A61K26518

Patent

active

058744304

ABSTRACT:
The present invention relates to benzoxazinones of formula I: ##STR1## or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, methods of using the same for treating viral infection or as an assay standard or reagent, and intermediates and processes for making the same.

REFERENCES:
patent: 4518597 (1985-05-01), Narr et al.
patent: 5519021 (1996-05-01), Young et al.
Chemical Abstracts, vol. 70, abstract 68383c, 1969.
Tordeux et al, J. Chem. Soc. Perkin Trans. 1990, 1, 1951-1957, "Reactions of Trifluoromethyl Bromide and Related Halides: Part 9. Comparison between Additions to Carbonyl Compounds, Enamines, and Sulpher Dioxide in the Presence of Zinc."
Kotun et al, J. Org. Chem. 1992, 57, 1124-1131, "Fluorinated Tertiary Alcohols and Alkoxides from Nucleophilic Trifluoromethylation of Carbonyl Compounds."
Prakash et al, J. Am. Chem. Soc. 1989, 111 (1), 393-395, "Fluoride-Induced Trifluoromethylation of Carbonyl Compounds with Trifluoromethyltrimethylsilane (TMS-CF.sub.3). A Trifluoromethide Equivalent."
Kitasume et al, J. Org. Chem. 1988, 53, 2349-2350, "A Remarkably Simple Perfluoroalkylation in the Presence of an Electron Mediator."
Krishnamurti et al, J. Org. Chem. 1991, 56, 984-989, "Preparation of Trifluoromethyl and Other Perfluoroalkyl Compounds with (Perfluoralkyl) trimethylsilanes."
Mack et al, J. Heterocyclic Chem. 1987, 24, 1733-1739, "The Preparation of Quinolines and Related Fused-Ring Heterocycles from the Dianions of Benzoylacetone, Certain Cyclic Ketone Oximes, or Certain Substituted Hydrazones."
Coppola et al, J. Org. Chem. 1976, 41 (5), 825-831, "Chemistry of 2H-3, 1-Benzoxazine-2,4(1H)-dione(Isatoic Anhydride). 2.Reactions with Thiopseudoureas and Carbanions."
Takimoto et al, Fukuoka Univ. Sci, Reports 1985, 15 (1), 37-38, "Reactions of Isatoic Anhydride with Various Nucleophiles in the Presence of 4-Pyrrolidinopyridine."
Kadin et al, Synthesis 1977, Jul., 500-501, "A Convenient Synthesis of 2-Amino-4-hydroxyquinolines."
Staiger et al, J. Org. Chem. 1959, 24, 1214-1219, "Isatoic Anhydride. IV. Reactions with Various Nucleophiles."

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-307199

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.