4,4-Dimethyl-3,5-pyrrolidinediones

Details 4,4-Dimethyl-3,5-pyrrolidinediones 4,4-Dimethyl-3,5-pyrrolidinediones

1976-10-15

1979-01-23

Tovar, Jose

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

26032644, 26032643, A61K 3140, C07D20740

Patent

active

041361903

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: n is 4 to 8, X is CO, protected CO or CROH wherein R is hydrogen or C.sub.1-4 alkyl and wherein the OH moiety may be protected; R.sub.1 is hydrogen, or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1 to 12 carbon atoms; R.sub.3 is hydroxy or protected hydroxy; R.sub.2 and R.sub.4 are separately hydrogen, C.sub.1-9 alkyl, C.sub.5-8 cycloalkyl, C.sub.5-8 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, naphthyl, naphthyl C.sub.1-6 alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or nitro groups; or R.sub.2 and R.sub.4 taken with the carbon atoms to which they are joined represent C.sub.5-8 cycloalkyl; A is hydrogen or a group CO.sub.2 B wherein B is hydrogen, or CO.sub.2 B represents an ester group in which the B moiety contains from 1 to 12 carbon atoms; or methyl; and salts thereof; have useful pharmacological properties including anti-gastric secretion, bronchodilator and platelet aggregration inhibition activities.

REFERENCES:
patent: 3975399 (1976-08-01), de Franco et al.
patent: 4003911 (1977-01-01), Scribner

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