4,4'-[9H-fluoren-9-ylidenebis (methylene)]bispyrimidine for trea

Details 4,4'-[9H-fluoren-9-ylidenebis (methylene)]bispyrimidine for trea 4,4'-[9H-fluoren-9-ylidenebis (methylene)]bispyrimidine for trea

1990-01-12

1992-02-11

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544294, A61K 31505, C07D23926

Patent

active

050876287

ABSTRACT:
A fluorene compound, 4,4'-[9H-fluoren-9-ylidenebis(methylene)]bispyrimidine, or a pharmaceutically acceptable salt thereof is useful in treating various neurological disorders in mammals. This compound has efficacy over a broad dosage range as measured by hypoxia induced cognition impairment and has a wide safety margin as measured by the ratio of cognition to the onset of overt symptoms.

REFERENCES:
patent: 4760083 (1988-07-01), Myers et al.
Earl, et al., C. A. 111:153,640u, (1989), vol. 111.

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