4,4,5,5-Tetradehydro-.omega.-aryl-11-deoxy-PGE.sub.1 , analogs

Details 4,4,5,5-Tetradehydro-.omega.-aryl-11-deoxy-PGE.sub.1 , analogs 4,4,5,5-Tetradehydro-.omega.-aryl-11-deoxy-PGE.sub.1 , analogs

1976-11-04

1977-11-08

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

2604109R, 260520B, C07C 6522

Patent

active

040575721

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which there is a triple bond between C-5 and C-6 or C-4 and C-5. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3773795 (1973-11-01), Bagli et al.
patent: 3816393 (1974-06-01), Hayashi et al.
Patterson, J. W., Jr., J. Org. Chem., vol. 39, No. 17, 1974, pp. 2506-2509.

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