4(3H)-quinazolinone derivatives and pharmaceutical compositions

Details 4(3H)-quinazolinone derivatives and pharmaceutical compositions 4(3H)-quinazolinone derivatives and pharmaceutical compositions

1989-07-26

1991-04-16

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544116, 544284, 544285, A61K 31505, C07D40112

Patent

active

050082663

ABSTRACT:
4(3H)-Quinazolinone derivative of formula (I) are provided. ##STR1## wherein R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, an aryl group, a substituted aryl group, or an aralkyl group; R.sub.2 is a C.sub.1 -C.sub.6 alkylamino group, a phenyl group, a substituted phenyl group, or a 5- or 6-membered heterocyclic group containing one or more N, O or S as a hetero atom or atoms, said heterocyclic group optionally being substituted or fused with a benzene ring; n is 1 or 2; or R.sub.2 represents a geranyl group or a dipyridylmethyl group together with the group --(CH.sub.2).sub.n --; and X is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a halogen atom, and pharmaceutically acceptable acid addition salts thereof. They are useful as antiucler agents.

REFERENCES:
patent: 4833144 (1989-05-01), Takahashi et al.
patent: 4861780 (1989-08-01), Toshihiro et al.
McCarty, et al., "J.A.C.S.", vol. 82, No. 4, 1960, pp. 964-966.
Chaurasia, "Agr. Biol. Chem.", vol. 32, No. 6, 1968, pp. 711-714.
Choubey (I), "Agr. Biol. Chem.", vol. 33, No. 8, 1969, pp. 1213-1216.
Bhargava, et al. (I), "Chemical Abstracts", vol. 70, 1969, col. 87738p.
Murav'eva et al., "Chemical Abstracts", vol. 70, 1969, vol. 96748u.
Bhargava et al. (II), "Chemical Abstracts", vol. 72, 1970, Col. 31737m.
Bhargava, et al. (III), "Chemical Abstracts", vol. 77, 1972, Col. 483882.
Bhargava et al. (IV), "Chemical Abstracts", vol. 77, 1972, Col. 114250j.
Choubey (II), "Chemical Abstracts", vol. 77, 1972, Col. 88423p.
Bhargava et al. (IV), "Chemical Abstracts", vol. 80, 1974, Col. 146101g.
Bhargava et al. (VI), "Chemical Abstracts", vol. 85, 1976, Col. 85:5582f.
Chaurasia et al., "Chemical Abstracts", vol. 98, 1983, Col. 98:4512q.
"Chemical Abstracts", vol. 101, 1984, Col. 101:38470v.
Lakhan et al., "Chemical Abstracts", vol. 107, 1987, Col. 107:228515k.
Sato et al., "Chemical Abstracts", vol. 108, 1988, Col. 108:94581p.
J. Chem. Soc., vol. 82, p. 964, (1960).
J. Med. Chem., vol. 26, p. 218-222, (1983).
Chem. Abstr., vol. 83, 131542q, (1975).
Chem. Abstr., vol. 92, 146713f, (1980).
Chem. Abstr., vol. 102, 220825n, (1980).
Chem. Abstr., vol. 99, 158376f, (1983).
Chem. Abstr., vol. 89, 109345e, (1978).
Chem. Abstr., vol. 62, 14670g, (1965).
Chem. Abstr., vol. 57, 10284g, (1962).
Chem. Abstr., vol. 107, 36462u, (1987).
Chem. Abstr., vol. 106 102196t, (1987).

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