4(3H)-pteridinones, preparation processes and drugs containing t

Details 4(3H)-pteridinones, preparation processes and drugs containing t 4(3H)-pteridinones, preparation processes and drugs containing t

1990-03-29

1992-12-01

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424464, 424456, 424422, 424436, 424489, 424401, 424479, 514252, 514258, A61K 912

Patent

active

051679493

ABSTRACT:
The present invention relates to 4(3H)-pteridinones represented by the formula: ##STR1## in which X is an oxygen atom or a sulphur atom, Y is a hydrogen atom, a lower alkyl radical, especially a methyl radical, at the 6-position or a hydroxyl group at the 7-position, R.sub.1 is a hydrogen atom, a lower alkyl radical, a substituted or unsubstituted phenyl radical, a benzyl radical, a methoxymethyl group, an acetyl group, a 2-acetoxyethyl group or a 2,2,2-trifluoroethyl group and R.sub.2 is a hydrogen atom or a lower alkyl radical, especially a methyl radical. Application of these compounds as anti-allergic drugs.

REFERENCES:
patent: 3159628 (1964-12-01), Pachter et al.
patent: 3426019 (1969-02-01), Pachter et al.
patent: 3426022 (1969-02-01), Nakanishi et al.
patent: 3732224 (1973-05-01), Jacobs
patent: 3819631 (1974-06-01), Broughton
patent: 3859287 (1975-01-01), Parish et al.
patent: 3895012 (1975-07-01), Liede et al.
patent: 4183934 (1980-01-01), Paris et al.
patent: 4361700 (1982-11-01), Purcell et al.
Journal of Medicinal Chemistry, vol. 15, 1972, pp. 210-211, American Chemical Society, Washington, D.C. U.S.; E. Felder et al.: "Synthesis of 4(3H)-pteridinones".
Neckers et al., Organic Chemistry, pp. 543 and 666-670, 1977.

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