4(3H)-pteridinone compounds

Details 4(3H)-pteridinone compounds 4(3H)-pteridinone compounds

1992-11-03

1993-12-14

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544407, 544409, 544257, A61K 31505

Patent

active

052704653

ABSTRACT:
The present invention relates to 4(3H)-pteridinones represented by the formula: ##STR1## in which X is an oxygen atom or a sulphur atom, Y is a hydrogen atom, a lower alkyl radical, especially a methyl radical, at the 6-position or a hydroxyl group at the 7-position, R.sub.1 is a hydrogen atom, a lower alkyl radical, a substituted or unsubstituted phenyl radical, a benzyl radical, a methoxymethyl group, an acetyl group, a 2-acetoxyethyl group or a 2,2,2-trifluoroethyl group and R.sub.2 is a hydrogen atom or a lower alkyl radical, especially a methyl radical.
Application of these compounds as anti-allergic drugs.

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Journal of Medicinal Chemistry, vol. 15, 1972, pp. 210-211, American Chemical Society, Washington, D.C. U.S.; E. Felder et al: "Synthesis of 4(3H)-pteridinones".

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