4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives

Details 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives

1987-11-13

1989-05-23

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, A61K 31505, C07D47104

Patent

active

048331457

ABSTRACT:
Derivatives of N-[4-(N-[2-amino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylme thyl]-amino)benzoyl]-L-glutamic acid are antineoplastic agents. Their preparation and use, and intermediates useful for their preparation are described.

REFERENCES:
patent: 3856959 (1974-12-01), Mead
patent: 4172200 (1979-10-01), Piper et al.
patent: 4369319 (1983-01-01), DeGraw et al.
patent: 4431805 (1985-02-01), Temple et al.
patent: 4432981 (1984-02-01), Lesher et al.
patent: 4460591 (1984-07-01), DeGraw et al.
patent: 4512992 (1985-04-01), Duch et al.
patent: 4526964 (1985-07-01), Temple et al.
patent: 4532241 (1985-07-01), DeGraw et al.
patent: 4536575 (1985-08-01), Temple et al.
patent: 4564616 (1986-01-01), Jones et al.
patent: 4684653 (1987-08-01), Taylor et al.
patent: 4725687 (1988-02-01), Piper et al.
Harrington, Synthetic Approaches to 5- Deaza and 5,10- Dideaza Folic Acid Analogs, Ph.D. Dissertation, Princeton U., 1982.
Moad et al., Jacs 101:20, 6068-6076 (9/27/76).
Jahine et al., Ind. J. Chem., 16B, 889-891 (10/78).
Sirotnak et al., Cancer Treat. Rep., 66:2 (2/82).
Troschutz et al., Arch. Pharm. 311, 406-414 (1978).
Temple et al., J. Org. Chem 47, 761-764 (1982).
Taylor et al., Chem. & Biology of Pteridines (Ed. J. A. Blair) Walter de Gruyter & Co., N.Y. 115-119 (1983).
Taylor et al., J. Org. Chem. 48, 4852-4860 (1983).
Taylor et al., J. Org. Chem. 50, 1005-1014 (1985).
DeGraw et al., J. Heterocycl. Chem. 19, 1461-1463 (1982).
Grivsky et al., J. Med. Chem. 23:3, 327-329 (1980).
Piper et al., J. Med. Chem. 23, 320-321 (1980).
DeGraw et al., J. Med. Chem 17:5, 552-553 (1974).
Elliott et al., J. Med. Chem. 17:5, 553-555 (1974).
Nair, J. Org. Chem., 50, 1879-1884 (1985).
Drugs of the Future, IV, No. 9, 641-644 (1979).
Sirotnak et al., Cancer Treat. Rep. 62:7, 1047-1052 (1978).
Stone et al., Biochem. Pharmac. 33:2, 175-179 (1984).
Srinivasan et al., J. Org. Chem., 45, 3746-3748 (1980).
Hurlbert et al., J. Med. Chem., 11, 703-717 (1968).
Rosowsky et al., J. Med. Chem., 17:12, 1872-1276 (1974).
Struck et al., J. Med. Chem., 14:8, 693-695 (1971).
CA 96:104757a Sirotnak et al. (1982).
Taylor et al., J. Med. Chem. 28:7, 914-921 (1985).
DeGraw et al., J. Heterocycl. Chem. 8, 105-110 (1971).
Oakes et al., J. Chem. Soc. (London) 4433 (1956).
Elslager et al., Lectures in Heterocyclic Chemistry, vol. 2, S-97; Supplement to J. Heterocyclic Chem., 11 (1974).
DeGraw et al. (VII), J. Med. Chem., 17:470 (1974).
DeGraw et al. (VIII), J. Heterocyclic Chem., 13:439 (1976).
Smith et al., Biochem. 20: 1241 (1981).
Temple et al. (V), J. Med. Chem. 24: 1254 (1981).
DeGraw et al. (IX), Chem. & Biolog. of Pteridines (Ed. Kisliuk/Brown) Elsevier, North Holland (229-234) (1979).
Srinivasan et al. (II), J. Org. Chem. 46: 1777 (1981).
Srinivasan et al. (III), Tetrahedron Lett. 23:1431 (1982).
DeGraw et al. (X), PCT Application WO85/02844 (Published Jul. 4, 1985).
Wheeler et al., J. Amer. Chem. Soc. 74:4725 (1952).
Kisliuk, R. L., Nature, 188:584 (1960).
Kisliuk et al. (II), J. Biol. Chem. 239: 1900 (1964).
Horwitz et al., J. Med. Chem. 11:907 (1968).

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