4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivative

Details 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivative 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivative

1987-04-20

1989-05-16

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, 544229, A61K 31505, C07D47104, C07F 708

Patent

active

048310379

ABSTRACT:
N-[4-(N'-[2-amino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylme thyl]-N'-acylamino)benzoyl]-L-glutamic acid derivatives are antineoplastic agents. The compounds are prepared through acylation of the corresponding N'-amino compound or hydrolysis of a protected N'-acylamino compound. A typical embodiment is N-[4-(N'-[2-amino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylm ethyl]-N'-formylamino)benzoyl]-L-glutamic acid.

REFERENCES:
patent: 4684653 (1987-08-01), Taylor et al.
Dedhar et al., Biochemical Pharmacology 32, pp. 922-924 (1983).
Dedhar et al., Chem. Abstract No. 16099u, vol. 99 (1983).
Taylor et al., J. Org. Chem. 48, p. 4852 (1983).
Temple et al., J. Med. Chem. 24, p. 1254 (1981).

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