4-(3-Amino-2-acyloxypropoxy)-1,2,5-thiadiazole compounds

Details 4-(3-Amino-2-acyloxypropoxy)-1,2,5-thiadiazole compounds 4-(3-Amino-2-acyloxypropoxy)-1,2,5-thiadiazole compounds

1975-02-26

1977-03-08

Sutto, Anton H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260268H, 260302D, C07D28510, C07D29512

Patent

active

040112179

ABSTRACT:
4-[3-(Substituted amino)-2-acyloxypropoxy]-1,2,5-thiadiazole compounds, optionally substituted in the 3-position of the thiadiazole nucleus which exhibit .beta.-adrenergic blocking properties and thus are useful in the management of angina pectoris are described. The products are prepared by reaction of a 4-[3-(substituted amino)-2-hydroxypropoxy]-1,2,5-thiadiazole with the appropriate anhydride. The reaction is run under acidic conditions when the amino nitrogen is protonated.

REFERENCES:
patent: 3655663 (1972-04-01), Wasson
patent: 3657237 (1972-04-01), Weinstock et al.
patent: 3729469 (1973-04-01), Wasson

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