4-[[3-[.alpha.-Aminobenzyl]phenyl]methyl]morpholine and 4-[-[3-b

Details 4-[[3-[.alpha.-Aminobenzyl]phenyl]methyl]morpholine and 4-[-[3-b 4-[[3-[.alpha.-Aminobenzyl]phenyl]methyl]morpholine and 4-[-[3-b

1980-02-15

1981-12-29

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544175, C07D29510, C07D29512

Patent

active

043083820

ABSTRACT:
N-{2, 3- and 4-[R.sub.1 -(phenyl)-C(=X)]-phenyl-lower-alkyl}amines, useful as anti-inflammatory agents, are prepared either by reduction of 2-, 3- or 4-[R.sub.1 -(phenyl)-CO]-phenyl-lower-alkanoylamines, which are also useful as anti-inflammatory agents; by benzoylating a phenyl-lower-alkylamine; by reaction of a 2-, 3- or 4-lithiophenyl-lower-alkylamine with a R.sub.1 -(phenyl)-carboxaldehyde, a R.sub.1 -(phenyl)-lower-alkyl ketone or a R.sub.1 -(phenyl)-carbonitrile; by reaction of a 2-, 3- or 4-[R.sub.1 -(phenyl)-CO]-phenyl-lower-alkyl tosylate with an appropriate amine; or by transformations involving manipulations of a carbonyl or carbinol group.

REFERENCES:
patent: 3123643 (1964-03-01), Palopoli et al.
patent: 3497508 (1970-02-01), Houlihan
patent: 3867381 (1975-02-01), Houlihan

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