4-(3-(4-Quinolyl)propyl)piperidines, their preparation and their

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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546153, 546156, 546184, A61K 3147, C07D21132, C07D40106

Patent

active

042371392

ABSTRACT:
Pharmaceutical preparations containing as active ingredient a compound having the formula: ##STR1## wherein R represents hydrogen, alkyl having 1 to 4 carbon atoms or alkenyl having 2 to 4 carbon atoms; and
X represents hydrogen, alkyl, alkoxy or alkylthio, the alkyl groups of each containing 1 to 4 carbon atoms, halogen (chlorine, fluorine, bromine or iodine), trifluoromethyl, nitro, hydroxy, amino or amino substituted by one or two alkyl groups or by acyl or alkylsulphonyl, the alkyl groups of each containing 1 to 4 carbon atoms, which are particularly advantageous for the treatment of pathological states caused by a disturbance in the functioning of the serotoninergical systems in mammals. These preparations may also be used as anxiolytics.

REFERENCES:
Popli et al., J. Sci. Ind. Res. Sect. c19, 298-302 (1960).
P. Rabe, Ber. 55, 532 (1922).
V. Prelog et Coll., Ber. Der Deutschen Chemischen Gesellschaft, 72B, 1325-1333 (1939).

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