Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-04-16
1991-07-23
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514278, 514321, 514322, 514326, 514230, 514360, 514364, 514369, 546 15, 546 20, 546198, 546199, 546201, 546209, 546216, 546217, 546225, A61K 31495, A61K 31445, C07D41706, C07D41714
Patent
active
050343920
ABSTRACT:
This invention relates to compounds of the formula ##STR1## where R.sub.1 and R.sub.2 are independently hydrogen or loweralkyl or R.sub.1 and R.sub.2 taken together with the carbon atom to which they are attached form a spiro-fused cycloalkane of 5 to 8 carbons; R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a spiro-fused cycloalkane of 5 to 8 carbons; R.sub.5 and R.sub.6 taken together with the nitrogen atom to which they are attached are ##STR2## where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, amino, cyano, trifluoromethyl or methoxy; and m is 0, 1 or 2; the pharmaceutically acceptable acid addition salts thereof and where applicable the optical and geometrical isomers and racemic mixtures thereof. The compounds of this invention are useful as analgesic and antihypertensive agents.
REFERENCES:
patent: 3354178 (1967-11-01), Dickinson
patent: 4933453 (1990-06-01), Hrib et al.
P. Moses et al., Acetylene Compounds of Potential Pharmacological Value, Acta. Pharm. Succ., 15, 1978, pp. 175-180.
Hoechst-Roussel Pharmaceuticals Incorporated
Korsen Elliott
Shen Cecilia
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