4-(3,4-Diaminophenyl)pyridine or salts, and use thereof as cardi

Details 4-(3,4-Diaminophenyl)pyridine or salts, and use thereof as cardi 4-(3,4-Diaminophenyl)pyridine or salts, and use thereof as cardi

1980-07-28

1981-10-27

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546329, C07D21338, A61K 3144

Patent

active

042973627

ABSTRACT:
4-(3,4-Diaminophenyl)pyridine, a cardiotonic agent, is prepared by reducing 4-(4-amino-3-nitrophenyl)pyridine or preferably by reacting 4-(4-acetylamino-3-nitrophenyl)pyridine or 4-(3-acetylamino-4-nitrophenyl)pyridine with stannous chloride and hydrochloric acid. 4-(3,4-diaminophenyl)pyridine or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active ingredient in a cardiotonic composition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment.

REFERENCES:
patent: 3891656 (1975-06-01), Fields
patent: 3994903 (1976-11-01), Carabateas et al.
Cook et al., Jour. of the Chemical Soc., pp. 404-406, (1943).
Coates, Jour. of the Chemical Soc., pp. 406-413, (1943).

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