4-(2-methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihy...

Details 4-(2-methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihy... 4-(2-methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihy...

2007-09-20

2009-08-04

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S112000, C546S152000, C514S229800, C514S311000

Reexamination Certificate

active

07569584

ABSTRACT:
The compound of the formulawherein the * indicates an asymmetric carbon, is specific to alpha2Badrenergic receptors in preference over alpha2Aand alpha2Cadrenergic receptors, and as such has no or only minimal cardivascular and/or sedatory activity. The compound is useful as medicament in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2Badrenergic receptors.

REFERENCES:
patent: 4798834 (1989-01-01), Merritt et al.
patent: 6313172 (2001-11-01), Chow et al.
patent: 6465486 (2002-10-01), Baxter et al.
patent: 6534542 (2003-03-01), Chow et al.
patent: 6545182 (2003-04-01), Chow et al.
patent: 7091232 (2006-08-01), Chow et al.
patent: 7276522 (2007-10-01), Heidelbaugh et al.
patent: 7396849 (2008-07-01), Heidelbaugh et al.
patent: 2002/0094998 (2002-07-01), Burke et al.
patent: 1 499 485 (1978-02-01), None
patent: WO 92/00073 (1992-01-01), None
patent: WO 99/28300 (1999-06-01), None
patent: WO 01/00586 (2001-01-01), None
patent: WO 02/36162 (2002-05-01), None
Messier et al, Pharmacol. Toxicol., 1995, p. 308-311, 76.
Conklin et al., Nature, 1993, p. 274-276, 363.
Dirig, et al., J. Neurosci. Methods, 1997, p. 183-191, 76.
Hargreaves, et al., Pain, 1988, p. 77-88, 32.
Kim et al., Pain, 1992, p. 355-363, 150.
Dixon et al., Ann. Rev. Pharmacol. Toxicol., 1980, p. 441-462, 20.
Cooke et al., J. Org. Chem., 1980, 45, 1046.
Horne et al., Heterocycles, 1994, 39,139.
Woods et al., J. Amer. Chem. Soc., 1949, 71, 2020.
Sosa et al., J. Org. Chem., 2002, 4498-4500, 67.
Hua et al., J. Org. Chem. 1997, 62, 6888.
Jennesken et al., J. Org. Chem. 1986, 51, 2162.
Kim et al., Synthesis, 1993, 283.
Kowalski et al., J. Org. Chem., 1982, 47, 5088.
Huang et al., Synthetic Communications, 1998, 28, 1197.
Ciufolini et al., J. Amer. Chem. Soc., 1991, 113, 8016.
Mancuso, Synthesis, 1981, pp. 165.
Corey et al., Tetrahedron Lett., 1989, 30, 6275.
Xavier et al., Organic Synthesis, 1996, 74, 50.
Molina et al., Tetrahedron, 1995, 51, 1265.
Lemke et al., J. Med. Chem., 1977, 20, 1351.
Berque et al., J. Org. Chem., 1999, 373.
Organ et al., J. Org. Chem., 1997, 62, 1523.

Affiliated with

Also associated with

Rating

4-(2-methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihy... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-(2-methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihy..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-(2-methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihy... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4087434