4-(2-Chloro- or methylthiopyrid-3-yl)-3,5-dicarbalkoxy-2,6-dimet

Details 4-(2-Chloro- or methylthiopyrid-3-yl)-3,5-dicarbalkoxy-2,6-dimet 4-(2-Chloro- or methylthiopyrid-3-yl)-3,5-dicarbalkoxy-2,6-dimet

1976-08-05

1978-06-20

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2602948G, 2602955R, C07D21355, A61K 31455

Patent

active

040962709

ABSTRACT:
This invention relates to substituted 1,4-dihydropyridines showing interesting physiological activities, particularly on the cardiovascular system. 1,4-Dihydropyridines in accordance with the invention are substituted in the 4-position by a 2-chloropyrid-3-yl or a 2-methylthiopyrid-3-yl group, in the 3- and 5-positions by a methoxycarbonyl or ethoxycarbonyl group and in the 2- and 6-positions by a methyl group. Acid addition salts of these compounds are included in the present invention. The compounds can be prepared by reacting an appropriate 2-substituted nicotinaldehyde with an alkyl acetoacetate. Compounds in accordance with the invention have shown anti-hypertensive activity at very low doses.

REFERENCES:
patent: 3773773 (1973-11-01), Bossert
patent: 3799934 (1974-03-01), Meyer et al.

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