4(1H)-quinolone derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544363, 546153, 546156, A61K 3147, C07D21522

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active

050811215

ABSTRACT:
Quinolone derivatives having a quinolone structure: ##STR1## where Yo is O or S are disclosed, which are useful as cardiotonic agents. Typical examples of the quinolone derivatives include: 6,7-dimethoxy-4 (1H) quinolone (compound 6) and 5-hydroxy-6-methoxy-4(1H) quinolone (compound 1) as typical compounds of the formulae[I] and [I'], respectively, shown in the specification.

REFERENCES:
patent: 2558211 (1957-06-01), Elderfield
patent: 3178348 (1965-04-01), Bickerton
patent: 4168311 (1979-09-01), Studeneer
patent: 4728647 (1988-03-01), Benavides
Chem. Abstracts, vol. 41, No. 12, 6-20-47, Snyderetal, "Synthesis of 4-Hydroxyquinolines" col. 3801, Abstract 3801e.
Chem. Abstracts, vol. 88, No. 7, 2-13-78, Renavetatal. "Appln. of Phase Transfer" p. 254, col. 2, Abstract No. 50 616.
Jiegou Huaxue (J. Struct. Chem.), vol. 5, No. 1, 1 (1986).

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