4-(1H-pyrrol-1-yl) imidazoles with angiotension II antagonist ac

Details 4-(1H-pyrrol-1-yl) imidazoles with angiotension II antagonist ac 4-(1H-pyrrol-1-yl) imidazoles with angiotension II antagonist ac

1992-05-19

1993-05-11

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483265, C07D40304, C07D23388, C07D23390

Patent

active

052102114

ABSTRACT:
Novel substituted 4-(1-H-pyrrol-1-yl)imidazoles are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and methods of using them. Novel intermediates useful in the preparation of the compounds of the invention are also disclosed and synthetic methods for preparing the novel intermediates. The compounds are useful as antagonists of angiotensin II and thus are useful in the control of hypertension, hyperaldosteronism, congestive heart failure, glaucoma, vascular smooth muscle proliferation associated with atherosclerosis, and with postsurgical vascular restenosis.

REFERENCES:
patent: 4820843 (1989-04-01), Aldrich et al.
Hypertension, 18[Suppl. II]:II60-II64 (1991).
Japan. J. Pharmacol., 52:541-552 (1990).
FASEB, 52(4):A869 (1990).

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