4-(1H-pyrrol-1-yl)imidazoles with angiotensin II antagonist acti

Details 4-(1H-pyrrol-1-yl)imidazoles with angiotensin II antagonist acti 4-(1H-pyrrol-1-yl)imidazoles with angiotensin II antagonist acti

1992-10-13

1994-01-04

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514397, 548250, 548252, 548253, 548254, 5483147, A61K 31415, C07D40314, C07D40304

Patent

active

052760480

ABSTRACT:
Novel substituted 4-(1-H-pyrrol-1-yl)imidazoles are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and methods of using them. Novel intermediates useful in the preparation of the compounds of the invention are also disclosed and synthetic methods for preparing the novel intermediates. The compounds are useful as antagonists of angiotensin II and thus are useful in the control of hypertension, hyperaldosteronism, congestive heart failure, glaucoma, vascular smooth muscle proliferation associated with atherosclerosis, and with postsurgical vascular restenosis.

REFERENCES:
Hypertension, 18[Suppl. II]:II60-II64 (1991).
Japan J. Pharmacol., 52:541-552 (1990).
FASEB, 52(4):A869 (1990).

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