4(1H)-pyrimidinones

Details 4(1H)-pyrimidinones 4(1H)-pyrimidinones

1973-09-04

1977-07-05

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602471M, 2602472A, 2602564C, 2602565R, 42424851, 42424852, 4242485, 42424854, C07D23922, A61K 31535

Patent

active

040340937

ABSTRACT:
Therapeutically-active and pharmacologically-acceptable 1-amido-5-cyano-4(1H)-pyrimidinones and their pharmaceutically-acceptable acid addition salts inhibit xanthineoxidase and are useful as the active ingredient in medicaments for the treatment of gout. Such pyrimidinones are prepared by treating 2-(acyl) hydrazonomethyl-3-chloro or hydroxy-4-aza-2,4-pentadienenitriles with acid.

REFERENCES:
patent: 2831833 (1958-04-01), Aycock et al.
Kloetzer et al., "Chemical Abstracts," vol. 66, 1967, Col. 46390t, (Abstract of Montash. Chem., vol. 96(6), 1965, pp. 1731-1738).

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