4-(1H-indol-3-yl)-.alpha.-methyl-piperidine-1-ethanol derivative

Details 4-(1H-indol-3-yl)-.alpha.-methyl-piperidine-1-ethanol derivative 4-(1H-indol-3-yl)-.alpha.-methyl-piperidine-1-ethanol derivative

1983-09-28

1985-07-23

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514323, 514333, 514339, 546193, 546201, 546256, 546273, C07D40104, A61K 3144

Patent

active

045309329

ABSTRACT:
Novel 4-(1H-indol-3-yl)-.alpha.-methyl-piperidine-1-ethanol derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, halogen, alkyl and alkoxy of 1 to 5 carbon atoms, --NO.sub.2, --NH.sub.2, CF.sub.3 -- and CH.sub.3 S--, R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and --OH, Ar is selected from the group consisting of optionally substituted aryl and heteroaryl, the dotted line indicates the optional presence of a double bond and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable antagonistic properties toward calcium ion and antihypertensive activity and certain compounds possess .alpha. and/or .beta.-blocking properties.

REFERENCES:
patent: 4100291 (1978-07-01), Clemence et al.
patent: 4224333 (1980-09-01), Clemence et al.
patent: 4264599 (1981-04-01), Eichenberger et al.
patent: 4324790 (1982-04-01), Guillanme et al.
patent: 4344945 (1982-08-01), Teranishi et al.
patent: 4344948 (1982-08-01), Takai et al.

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