4-1BB polypeptides and DNA encoding 4-1BB polypeptides

Details 4-1BB polypeptides and DNA encoding 4-1BB polypeptides 4-1BB polypeptides and DNA encoding 4-1BB polypeptides

2007-05-01

2007-05-01

Spector, Lorraine (Department: 1647)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S134100, C424S192100, C530S350000, C530S387300, C536S023500, C536S024310, C435S069100, C435S069700, C435S325000, C435S361000

Reexamination Certificate

active

08910449

ABSTRACT:
Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.

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