4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate an

Details 4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate an 4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate an

1982-02-10

1986-08-19

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548335, A61K 31415, C07D23360

Patent

active

046070460

ABSTRACT:
4-(1-Imidazolylmethyl)cinnamic acid hydrochloride monohydrate of the formula: ##STR1## and pharmaceutical compositions containing such compound. The imidazole derivative above has a strong and specific inhibitory effect on thromboxane synthetase from human or bovine platelet microsomes, and is useful as a therapeutical agent for inflammation, hypertension, thrombus, cerebral apoplexy, and asthma.

REFERENCES:
patent: 4226878 (1980-10-01), Iizuka et al.
Ogata et al., Kagaku Jikken Sosaho, (1958), pp. 403, 414, 415.

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