Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-05-31
1996-10-29
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544239, A61K 3150
Patent
active
055696570
ABSTRACT:
The compound (-)-[[4-(1,4,5,6 tetrahydro-4-methyl-6-oxo-3 pyridazinyl) phenyl]-hydrazono] propane dinitrile and its salts are prepared and used for treating congestive heart failure.
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J. Org. Chem. 1991, 56, 1963-1966, An Enantioselective Synthesis of SK&F 93505, A Key Intermediate For Preparing Cardiotonic Agents by Franklin F. Owings, Margaret Fox, Conrad J. Kowalski, and Neil H. Baine.
Journal of Medicinal Chemistry, 1974, vol. 17, No. 3, pp. 273-281, 6-Phenyl-4,5-Dihydro-3(2H)-Pyridazinones. A Series of Hypotensive Agents by William V. Curran and Adma Ross.
"Synthesis and Biological Activity of Four Stereoisomers of 6-[4-[3-[[2[Hydroxy-3-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]propyl]amino ]-propionamido]phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone, a Combined Vasodilator and .beta.-Adrenoceptor Antagonist", W. Howson et al., J. Med. Chem. 1988, vol. 31, pp. 352-356.
B ackstr om Reijo
Haarala Jorma
Haikala Heimo
Honkanen Erkki
Nore Pentti
Daus Donald G.
Orion-yhtyma Oy
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