4-(1,1-dialkoxycarbonylalkyl)azetidin-2-one derivative and proce

Details 4-(1,1-dialkoxycarbonylalkyl)azetidin-2-one derivative and proce 4-(1,1-dialkoxycarbonylalkyl)azetidin-2-one derivative and proce

1992-12-09

1994-12-06

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20508

Patent

active

053712145

ABSTRACT:
A 4-(1,1-dialkoxycarbonylalkyl )azetidin-2-one derivative represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are identical or different and each represents an alkyl group, an alkenyl group, or an aralkyl group, R.sup.3 represents a lower alkyl group, R.sup.4 represents a hydrogen atom or a hydroxyl-protective group, and R.sup.5 represents a hydrogen atom or an amino-protective group, and a process for producing a 4-(1-carboxyalkyl)azetidin-2-one derivative represented by formula (II) useful as an intermediate for 1.beta.-alkylcarbapenem-type antibacterials: ##STR2## wherein R.sup.3 represents a lower alkyl group and R.sup.4 represents a hydrogen atom or a hydroxyl-protective group, which comprises de-esterifying and decarboxylating the derivative represented by formula (I), and in the case where an amino-protective group is present in the derivative of formula (I), eliminating the protective group from the derivative, are disclosed.

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