(3S-4S)-7-hydroxy-.DELTA..sup.6 -tetrahydrocannabinols

Details (3S-4S)-7-hydroxy-.DELTA..sup.6 -tetrahydrocannabinols (3S-4S)-7-hydroxy-.DELTA..sup.6 -tetrahydrocannabinols

1987-10-26

1989-10-24

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549390, 549391, A61K 3135, C07D31180

Patent

active

048762768

ABSTRACT:
The invention relates to novel (3S,4S)-7-hydroxy-.DELTA..sup.6 -tetrahydrocannabinol homologes and derivatives, essentially free of the (3R,4R) form and to pharmaceutical compositions which have a potent analgetic, antiemetic and antiglaucoma effect, which compositions contain an effective dosage of a compound of this type. The novel pharmaceutical compositions are practically devoid of the undesired side effects of the (3R,4R) type compounds, such as cannabimimetic psychotropic effects. The pharmaceutical compositions are of special utility in cases of acute and of chronic pain. The invention also relates to a process for the production of the above defined novel compounds.

REFERENCES:
patent: 3873576 (1975-03-01), Petrizilka
patent: 4075230 (1978-02-01), Archer et al.
patent: 4102902 (1978-07-01), Archer et al.
patent: 4133819 (1979-01-01), Johnson
patent: 4179517 (1979-12-01), Mechoulam et al.
R. Mechoulam, Ed., Cannabinoids as Therapeutic Agents, CRC Press, Boca Ba, Fl., 1986, pp. 66-67, 79, 115.

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