Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-03-06
1987-02-03
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544335, A61K 31505, C07D23902
Patent
active
046409220
ABSTRACT:
A 3N-substituted 3,4-dihydropyrimidine derivative of the formula: ##STR1## wherein R.sup.1 is methyl or ethyl, R.sup.2 is methyl or ethyl, R is phenyl or substituted phenyl, X is chloro or methyl and pharmaceutically acceptable acid addition salts thereof have substantially the same strong vasodilative and Ca.sup.++ antagonistic effects as nicardipine and therefore are useful as agents for treating disorders of the cardiovascular system, for example, hypotensive agents, agents for amelioration of brain circulation and anti-angina pectoris agents.
Processes for producing the above compounds economically and effectively are also disclosed.
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Stoltefuss et al., Chem. Abst. 101-55110v.
Cho et al., Chem. Abst. 103-178228p.
Aisaka Kazuo
Cho Hidetsura
Emon Mariko
Daus Donald G.
Shen Cecilia
Suntory Limited
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