3A,4,7,7a-tetrahydro-3,6,7a-trimethyl-4-substituted phenyl-isoxa

Details 3A,4,7,7a-tetrahydro-3,6,7a-trimethyl-4-substituted phenyl-isoxa 3A,4,7,7a-tetrahydro-3,6,7a-trimethyl-4-substituted phenyl-isoxa

1984-12-21

1986-06-03

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49804

Patent

active

045931003

ABSTRACT:
Disclosed herein are 4-phenyl-tetrahydro-isoxazolo[5,4-b]-pyridine-5-carboxylic acid esters of Formula I: ##STR1## wherein Ar is phenyl or phenyl substituted by a halogen, nitro, or trifluoromethyl group; R.sup.1 is C.sub.1-3 alkyl; and R.sup.2 is C.sub.1-5 alkyl, (C.sub.1-5) alkoxy (C.sub.1-3)-alkyl, or mono- or di(C.sub.1-5) alkylamino (C.sub.1-3)alkyl;
or physiologically acceptable acid addition salts thereof. The compounds of the invention exhibit calcium antagonist and antihypertensive properties in standard pharmacological procedures.

REFERENCES:
Burrows et al., Journal of the American Chemical Society, 79, 3756 (1957).

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