38-decarboxy-38-hydroxymethyl derivatives of teiocoplanin antibi

Details 38-decarboxy-38-hydroxymethyl derivatives of teiocoplanin antibi 38-decarboxy-38-hydroxymethyl derivatives of teiocoplanin antibi

1997-06-10

1999-02-09

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 514 8, 514 2, 530317, 530322, 530321, 530345, 930190, A61K 3812, C07K 1102

Patent

active

058694498

ABSTRACT:
The present invention is directed to novel 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antiobiotics and a process for preparing them which includes submitted the corresponding lower alkyl ester precursor to a reduction reaction in the presence of an alkali metal borohydride. The compounds of the invention show an improved antibacterial activity against some clinical isolates of Staphylococci somewhat resistant to teicoplanin.
The teicoplanin derivatives of the present invention are represented by the following formula: ##STR1## wherein: X represents hydroxymethyl; acyl!-.beta.-D-2-deoxy-2-aminoglucopyranosyl;

REFERENCES:
patent: 4239751 (1980-12-01), Coronelli et al.
patent: 4542018 (1985-09-01), Borghi et al.
patent: 4594187 (1986-06-01), Strazzolini et al.
patent: 4629781 (1986-12-01), Strazzolini et al.
patent: 4650855 (1987-03-01), Malabarba et al.
patent: 4782042 (1988-11-01), Selva et al.
patent: 4789661 (1988-12-01), Malabarba et al.
patent: 4868171 (1989-09-01), Selva et al.
patent: 4882419 (1989-11-01), Malabarba et al.
patent: 4914187 (1990-04-01), Malabarba et al.
patent: 4935238 (1990-06-01), Selva et al.
patent: 4954483 (1990-09-01), Malabarba et al.
patent: 5064811 (1991-11-01), Borghi et al.
patent: 5085990 (1992-02-01), Lancini et al.
patent: 5185320 (1993-02-01), Trani et al.
patent: 5194424 (1993-03-01), Malabarba et al.
patent: 5198418 (1993-03-01), Malabarba et al.
patent: 5438117 (1995-08-01), Malabarba et al.
patent: 5500410 (1996-03-01), Malabarba et al.
patent: 5521155 (1996-05-01), Malabarba et al.
patent: 5567676 (1996-10-01), Selva et al.
patent: 5602229 (1997-02-01), Malabarba et al.
patent: 5606036 (1997-02-01), Hermann et al.
patent: 5644025 (1997-07-01), Malabarba et al.
patent: 5648456 (1997-07-01), Malabarba et al.
patent: 5674840 (1997-10-01), Malabarba et al.
Jentoft et al, The Journal of Biological Chemistry, vol. 254(11), pp. 4359-4365 (Jun. 10, 1979).
The Merck Manual of Diagnosis & Therapy, 11.sup.th ed., pp. 799-802, (1966) .

Affiliated with

Also associated with

Rating

38-decarboxy-38-hydroxymethyl derivatives of teiocoplanin antibi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 38-decarboxy-38-hydroxymethyl derivatives of teiocoplanin antibi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 38-decarboxy-38-hydroxymethyl derivatives of teiocoplanin antibi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1948466