33945, a human glycosyltransferase family member and uses...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

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C435S004000, C435S006120, C435S018000, C435S041000, C435S069100, C435S183000, C435S252300, C435S320100, C435S325000, C536S023200, C536S023400, C536S023500

Reexamination Certificate

active

06939698

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated 33945 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33945 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33945 gene has been introduced or disrupted. The invention still further provides isolated 33945 proteins, fusion proteins, antigenic peptides and anti-33945 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
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patent: 2003/0186850 (2003-10-01), Clausen et al.
patent: WO 00/55351 (2000-09-01), None
patent: WO 02/46426 (2002-06-01), None
White, Thayer et al. “Purification and cDNA Cloning of a Human UDP-N-acetyla-α-D-galactosamine:polypeptide N-Acetylgalactosaminyltransferase”The Journal of Biological Chemistryvol. 270, No. 41, (Oct. 13, 1995) pp. 24156-24165.
Strausberg, R., “Homo sapiens, Similar to hypothetical protein FLJ21212, clone MGC:24384 IMAGE:4064736; mRNA, complete cds.”, Sep. 10, 2001 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology information [retrieved on Aug. 19, 2002]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. BC013945.
Kawabata, A., et al., “Homo sapienscDNA: FLJ21212 fis, clone COL00502” Sep. 29, 2000 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Aug. 19, 2002]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AK024865.
Osada, N., et. al., “Macaca fascicularisbrain cDNA, clone:QnpA-17439” Sep. 20, 2000 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Aug. 19, 2002]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AB048901.
Hagen, F.K., et. al., “polypeptide GaINAc transferase-T4 [Mus musculus].” May 26, 1997 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Aug. 19, 2002]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AAB58301.

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