Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-07-17
2007-07-17
Campell, Bruce R. (Department: 1648)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S091400, C424S228100, C536S024100
Reexamination Certificate
active
09587653
ABSTRACT:
The present invention relates generally to the fields of biochemistry, molecular biology, and virology. More particularly, it relates to the identification of 259 nucleotides located at the 3′ end of the GB virus B (GBV-B) genome. The invention involves nucleic acid constructs and compositions encoding GBV-B sequence, including the 3′ end of the sequence, which has allowed an infectious GBV-B clone to be constructed. This construct, and chimeric versions of it, may be employed to study GBV-B and related hepatitis family members, such as hepatitis C virus. The invention thus includes methods of preparing GBV-B-containing sequences, constructs, and viruses, as well as methods of employing these compositions.
REFERENCES:
patent: 5672350 (1997-09-01), Parker et al.
patent: 5807670 (1998-09-01), Muerhoff et al.
patent: 6627437 (2003-09-01), Traboni
Buckwold et al. Antiviral Research 2005, vol. 66, pp. 165-168.
Bukh et al. Virol. Sep. 1999, vol. 262, No. 2, pp. 470-478.
Sbardellati et al. J Gene. Virol. 2001, vol. 82, pp. 2437-2448.
NCBI AJ277947 p. 1-5.
The HIV Life Cycle, published by OpenChemist.Net on Jun. 5, 2006, pp. 1-15.
Brass et al. Int. J. Med. 2006, vol. 3, pp. 29-34.
Bartenschlager et al. J. Gene. Viro. 2000, vol. 81, pp. 1631-1648.
Virus Repication published by Microbiology @ Leicester: Virology on Oct. 22, 2004, pp. 1-20.
The Free Dictionary by FARLEX on line, Google searches on Aug. 11, 2006, pp. 1-2.
Al et al., “Expression of recombinant hepatitis C virus in non-structural protein 5BEscherichia coli.,” Virus Res53:141-149, 1998.
Beard et al. “An infectious molecular clone of a japanese genotype 1b hepatitis c virus,”Hepatology, 30:316-324 1999.
Behrens et al., “Identification and properties of the RNA dependent RNA polymerase of hepatitis C virus,”EMBO J, 15:12-22, 1996.
Chambers et al., “Yellow fever/Japanese encephalitis chimeric viruses. construction and biological properties,”J Virol, 73:3095-3101, 1999.
Choo et al., “Vaccination of chimpanzees against infection by the hepatitis C virus,”Proc Natl Acad Sci USA, 91:1294-1298, 1994.
Farci et al., “Lack of protective immunity against reinfection with hepatitis c virus,”Science, 258:135-140. 1992.
Farci et al., “The natural history of infection with hepatitis C virus (HCV) in chimpanzees: Comparison of serologic responses measured with first- and second-generation assays and relationship to HCV viremia,”The Journal of Infectous Diseases, 165:1006-1011, 1992.
Frolov et al., “Cis-acting RNA elements required for replication of bovine viral diarrhea virus-hepatitis C virus 5′ nontranslated region chimeras,”RNA4:1418-1435, 1998.
Hijikata et al., “Two distinct protease activites required for the processing of a putative nonstructural precursor protein of hepatitis C virus,”J Virol, 67:4665-4675, 1993.
Honda et al., “Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatits C virus RNA,”RNA, 2:955-968, 1996.
Karayiannis et al., “Studies of GB hepatitis agent in tamarins,”Hepatology, 9:186-192, 1989.
Kim et al., “Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A confactor peptide,”Cell, 87:343-355, 1996.
Kolykhalov et al., “Transmission of hepatitis C by intrahepatic inoculation of transcribed RNA,”Science, 277:570-574, 1997.
Kolykhalov et al., “Identification of a highly conserved element at the 3′ terminus of hepatitis C virus genome RNA,”J Virol, 70:3363-3371, 1996.
Lemon and Honda, “Internal ribosome entry sites within the RNA genomes of hepatitis C virus and other flaviviruses,”Seminars in Virology, 8:274-288, 1997.
Lu and Wimmer, “Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus,”Proc Natl Acad Sci USA, 93:1412-1417, 1996.
Muerhoff et al., “Genomic organisation of GB viruses A and B: Two new members of the flaviviridae associated with GB agent hepatitis,”J Virol, 69:5621-5630, 1995.
Pletnev et al., “Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses,”Proc. Natl Acad Sci USA, 89:10532-10536, 1992.
Reynolds et al., “Unique features of internal initiation of hepatitis C virus RNA translation,”EMBO J, 14:6010-6020, 1995.
Rijnbrand et al., “Mutational analysis of the GB virus B internal ribosome entry site,”J Virol, 74:773-783, 2000.
Scarselli et al., “GB virus B and hepatitis C virus share substrate specificity,”J Virol, 74:4985-4989, 1997.
Schlauder et al., “Molecular and serological analysis in the transmission of the GB hepatitis agent,”J Med Virol, 46:81-90, 1995.
Shaffer et al., “A hepatitis A virus deletion mutant which lacks the first pyrimidine-rich tract of the 5′ nontranslated RNA remains virulent in primates after direct intrahepatic nucleic acid transfection,”J Virol, 69:6600-6604, 1995.
Simons et al., “Identification of two flavivirus like genomes in the GB hepatitis agent,”Proc Natl Acad Sci, 92:3401-3405, 1995.
Tanaka et al., “A novel sequence found at the 3′ terminus of hepatitis C virus genome,”Biochem Biophys Res Comm, 215:744-749, 1995.
Todd et al., “Replication competent picornaviruses with complete genomic RNA 3′ non-coding deletions,”J Virol, 71:8868-8874, 1997.
Yanagi et al., “Transcripts from a single full length cdna clone of hepatitius c virus are infectious when directly transfected into a liver of a chimpanzee,”Proc Natl Acad Sci USA, 94:8738-8743, 1998.
Yao et al., “Structure of the hepatitis C virus RNA helicase domain,”Nature Structural Biology, 4:463-467, 1997.
Zhao et al., “Poliovirus/hepatitis C virus (internal ribosome entry site-core) chimeric viruses: improved growth properties through modification of a proteolytic cleavage site and requirement for core RNA sequence but not for core related polypeptides,”J Virol, 73:1546-1554, 1999.
Lemon Stanley M.
Sangar David V.
Bao Qun Li
Campell Bruce R.
Fulbright & Jaworski L.L.P.
The Board of Regents of The University of Texas System
LandOfFree
3′ Sequence of the GB virus B (GBV-B) genome does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3′ Sequence of the GB virus B (GBV-B) genome, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3′ Sequence of the GB virus B (GBV-B) genome will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3733960