3-Vinylcephalosporin derivatives

Details 3-Vinylcephalosporin derivatives 3-Vinylcephalosporin derivatives

1981-11-19

1983-12-27

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

542420, 542437, C07D50124

Patent

active

044232144

ABSTRACT:
New 3-vinylcephalosporin derivatives of the general formula: ##STR1## in the form of a bicyclooct-2-ene or bicyclooct-3-ene, in which formula R.sub.5.sup.a and R.sub.5.sup.b are hydrogen atoms or alkyl radicals, or together form an alkyl radical containing 2 or 3 carbon atoms, R.sub.5.sup.c is an acid-protecting radical, R.sub.1 is an amino-protecting radical, R.sub.2 is an acid-protecting radical or a radical which can be removed by an enzymatic method, and R.sub.3 and R.sub.4, which are identical or different, represent alkyl (optionally substituted by hydroxyl, alkoxy, amino, alkylamino or dialkylamino) or phenyl, or together form, with the nitrogen atom, a saturated heterocyclic ring of 5 or 6 members, optionally containing another hetero-atom, their E and Z forms, and their syn and anti forms, and mixtures thereof, and also their preparation. These new compounds are useful as intermediates for the preparation of biologically active cephalosporins.

REFERENCES:
patent: 4278793 (1981-09-01), Durckheimer et al.
patent: 4307233 (1981-12-01), Farge et al.

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