3-Vinyl-cephalosporin derivatives

Details 3-Vinyl-cephalosporin derivatives 3-Vinyl-cephalosporin derivatives

1980-05-21

1981-12-22

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

542413, 542420, 542437, 542443, 544 22, 544 29, C07D50124

Patent

active

043072330

ABSTRACT:
Novel 3-vinyl-cephalosporin derivates of the general formula ##STR1## in the bicyclooct-2-ene or bicyclooct-3-ene form, in which R.sub.1 is a protective radical or is a radical of the general formula ##STR2## in which R.sub.5 is hydrogen, alkyl, vinyl or cyanomethyl, or a protective radical, and R.sub.6 is hydrogen or a protective radical, and R.sub.2 is a protective radical or an enzymatically removable radical, or R.sub.1 is an acyl radical, which may carry various substituents, and R.sub.2 represents a protective radical, and R.sub.3 and R.sub.4, which are identical or different, represent alkyl (optionally substituted by hydroxyl, alkoxy, amino, alkylamino or dialkylamino) or phenyl, or form, together with the nitrogen atom, a saturated 5-membered or 6-membered heterocyclic ring optionally containing another hetero-atom, their E- and Z-forms and their mixtures, are useful as intermediates for the preparation of 3-thiovinyl cephalosporins useful as antibacterial agents.

REFERENCES:
patent: 4065620 (1977-12-01), Webber
patent: 4098888 (1978-07-01), Ochiai et al.
patent: 4103084 (1978-07-01), Bradshaw et al.

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