3-(Trisubstituted benzoyl)-propionic acid

Details 3-(Trisubstituted benzoyl)-propionic acid 3-(Trisubstituted benzoyl)-propionic acid

1972-09-12

1976-03-09

Terapane, John F.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603403, 2603405, 2603406, 260465R, 260465D, 260516, 424278, 424317, C07C 6500, C07C 6522

Patent

active

039431690

ABSTRACT:
The present invention relates to a compound of the formula: ##SPC1##
Wherein R.sub.1 is an alkyl group of 1 to 4 carbons, an alkoxy group of 1 to 4 carbons or hydroxyl, and R.sub.2 and R.sub.3 are either the same or different and may be an alkyl group of 1 to 4 carbons, an alkoxy group of 1 to 4 carbons, hydroxyl, halogen or an alkylthio group of 1 to 4 carbons, or they are, connecting with each other, an alkylenedioxy group of 1 to 3 carbons, with the proviso that when R.sub.1 is an alkoxy group, at least one of R.sub.2 and R.sub.3 is an alkoxy group or an alkylthio group, or R.sub.2 and R.sub.3 are, connecting with each other, an alkylenedioxy group; when R.sub.1 is an alkyl group or hydroxyl, R.sub.2 and R.sub.3 are the same or different and may be an alkoxy group, an alkylthio group or, connecting with each other, an alkylene dioxy group; when R.sub.2 and R.sub.3 are methoxy, R.sub.1 is an alkyl group of 2 or 3 carbons, an alkoxy group of 2 to 4 carbons or hydroxyl, and when R.sub.2 is methyl and R.sub.3 is methoxy, R.sub.1 is an alkoxy group of 2 to 4 carbons or its pharmaceutically acceptable salts. The present invention also provides for a method of preparing the aforementioned compounds. The present compounds are characterized by exhibiting strong spasmolytic or relaxing action on the gall bladder, the common biliary duct, as well as exhibiting strong choleric activity and low toxicity.

REFERENCES:
patent: 2720542 (1955-10-01), Newhall
patent: 3502679 (1970-03-01), Houlihan et al.
patent: 3509132 (1970-04-01), Houlihan
patent: 3515731 (1970-06-01), Conover
Sharma et al., J. Ind. Chem. Soc., 36, No. 2, 117, (1959).
Tatsuo Shoji, Chem. Abst., 54, 5587d.
Chakravarti et al., J. Indian. Chem. Soc., 44, 6, (1967).
Bargellini et al., C.A., 6, 2417.sup.6.
Widmer et al., C.A., 63, 1747b, (1965).
Tateishi et al., Tetrahedron, 27, 237, (1971).
Irani et al., C.A., 45, 1974e, (1951).
Dalal et al., C.A., 32, 526.sup.6.
Coillard et al., C.A., 48:5841h.
Davies et al., C.A., 50, 7760d.
Zymalkowski et al., Archiv. Pharm. 299(6), 545, (1966).
Momose et al., C.A., 50, 911.

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