3-thio or amino substituted-benzo[b]thiophene-2-carboxamides and

Details 3-thio or amino substituted-benzo[b]thiophene-2-carboxamides and 3-thio or amino substituted-benzo[b]thiophene-2-carboxamides and

1993-08-18

1994-09-27

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142335, 5142315, 514445, 544146, A61K 31535, A01N 4306, C07D41306

Patent

active

053507487

ABSTRACT:
3-Thio or amino substituted benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted benzofuran-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of manufacture are also described.
The same benzo[b]thiophene and benzofuran-2-carboxamides also inhibit the activation of human immunodeficiency virus (HIV), latent in infected mammals.

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