3-Sulfonate ester of 2,3-dihydroxypropylamine

Details 3-Sulfonate ester of 2,3-dihydroxypropylamine 3-Sulfonate ester of 2,3-dihydroxypropylamine

1975-10-24

1977-06-21

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C14368

Patent

active

040311252

ABSTRACT:
Preparation of an optically active alkamine in the sinister configuration, or a derivative of said alkamine, which is reacted with an 3-X-4-chloro(or RO- where R is hydrogen or an alkali metal)-1,2,5-thiadiazole to prepare S-3-X-4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazole beta adrenergic blocking agents. Novel 3-morpholino-4-chloro(or RO-)-1,2,5-thiadiazoles and their preparation also are described.

REFERENCES:
patent: 2784233 (1957-03-01), Kottler et al.
Harris, J. Org. Chem., 28, 745 (1963).

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