3-Substituted-ureido-N-pyridyl benzamides

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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546337, C07D21375

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active

045007144

ABSTRACT:
Benzamide derivatives of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a methyl group or a methoxy group; R.sub.2 is a straight-chain or branched-chain alkyl group having 2 to 8 carbon atoms, a substituted phenyl group, or group --NHR.sub.4, R.sub.4 being a hydrogen atom, a straight-chain or branched-chain or cyclic alkyl group having 1 to 6 carbon atoms, or a phenyl group that may have a substituent on the nucleus; R.sub.3 is a hydrogen atom or one or two alkyl groups having 1 to 4 carbon atoms and n is 0 or 1, a process for preparing these derivatives, and pharmaceutical compositions containing the same are provided.
The compounds of the above formula have the action to reduce the blood glucose level and, therefore, are useful as medicines.

REFERENCES:
patent: 4035373 (1977-07-01), Roll
patent: 4044147 (1977-08-01), Nelson
patent: 4069224 (1978-01-01), Callahan et al.
patent: 4093734 (1978-06-01), Kruger et al.
J. Med. Chem., 14 963-968 (1971).
J. Med. Chem., 13 280-284 (1970).

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