3-substituted urea derivatives and medicinal use thereof

Details 3-substituted urea derivatives and medicinal use thereof 3-substituted urea derivatives and medicinal use thereof

2006-09-12

2006-09-12

O'Sullivan, Peter G. (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S596000, C514S597000, C514S598000, C564S048000, C564S050000, C564S051000, C564S052000, C564S053000, C564S054000, C549S439000

Reexamination Certificate

active

07105567

ABSTRACT:
The present invention relates to a urea derivative of the formula (1)wherein each symbol is as described in the specification, a pharmaceutically acceptable salt thereof and pharmaceutical use thereof. The compound of the present invention has a C5a receptor antagonistic action and is useful as an agent for the prophylaxis or treatment of diseases or syndromes due to inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis, pancreatitis and the like) due to activation of leukocytes caused by ischemia, trauma, burn, surgical invasion and the like]. In addition, it is useful as an agent for the prophylaxis or treatment of infectious diseases caused by bacteria or virus that invades via a C5a receptor.

REFERENCES:
patent: 4405644 (1983-09-01), Kabbe et al.
patent: 4868210 (1989-09-01), Trivedi
patent: 5063247 (1991-11-01), Sekiya et al.
patent: 0 512 570 (1992-11-01), None
patent: 512570 (1992-11-01), None
patent: 930918 (1963-07-01), None
patent: 10-182648 (1998-07-01), None
patent: WO 94/07815 (1994-04-01), None
patent: 98/07418 (1998-02-01), None
patent: WO 99/00406 (1999-01-01), None
C. Gerard et al., “C5a Anaphylatoxin and its Seven Transmembrane-Segment Receptor”, Annu. Rev. Immunol., vol. 12, pp. 775-808, 1994.
J. Ember et al., “Complement Factors and Their Receptors”, Immunopharmacology, vol. 38, pp. 3-15, 1997.
T. Pellas et al., “C5a Receptor Antagonists”, Current Pharmaceutical Design, vol. 5, pp. 737-755, 1999.
A. Wong et al., “Development of C5a Receptor Antagonists”, IDrugs, vol. 2, pp. 686-693, 1999.
Lanza et al., “Substituted 4, 6-diaminoquinolines as inhibitors of C5a receptor binding”,Journal of Medicinal Chemistry, vol. 35, No. 2, pp. 252-258, 1992.

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