Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1977-12-28
1980-08-19
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
260239A, 2602452T, 2602454, 2603457R, 424263, 424269, 424270, 424272, 542420, 544 90, 546256, 546272, C07D48704, A61K 3140
Patent
active
042184630
ABSTRACT:
Disclosed are 3-substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acids having the structure: ##STR1## wherein: R.sup.1 is hydrogen or acyl and R.sup.8 is, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
REFERENCES:
patent: 3950357 (1976-04-01), Kahan
Christensen Burton G.
Guthikonda Ravindra N.
Johnston David B. R.
Schmitt Susan M.
Arno James A.
Lee Mary C.
Levitt Julian S.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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