Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-10-15
1981-07-07
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602452T, 424269, 424270, 424272, 424274, 546272, C07D48704, A61K 3140, A61K 3144
Patent
active
042774829
ABSTRACT:
Disclosed are S-oxides of 3-substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acids having the structure: ##STR1## wherein: n is 1 or 2; R.sup.1 is hydrogen or acyl; and R.sup.8 is, inter alia, independently selected from the group consisting of alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
REFERENCES:
patent: 4123547 (1978-10-01), Christensen et al.
patent: 4150145 (1979-04-01), Christensen et al.
patent: 4181733 (1980-01-01), Christensen et al.
patent: 4218463 (1980-08-01), Christensen et al.
patent: 4224336 (1980-09-01), Christensen et al.
Christensen Burton G.
Guthikonda Ravindra N.
Johnston David B. R.
Schmitt Susan M.
Arno James A.
Lee Mary C.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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