3'-Substituted quinolinium cephalosporins

Details 3'-Substituted quinolinium cephalosporins 3'-Substituted quinolinium cephalosporins

1981-09-08

1983-05-10

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 22, 544 27, 544 28, 548133, 548233, 548245, A61K 31545, C07D50146

Patent

active

043829317

ABSTRACT:
Broad spectrum cephalosporin antibiotics represented by the formula ##STR1## are provided. In the formula, R represents a 2-aminooxazol-4-yl, 5-amino-1,2,4-oxadiazol-3-yl, or 5-aminoisoxazol-3-yl heterocyclic group; R' is hydrogen, C.sub.1 -C.sub.4 alkyl, a carboxy-substituted alkyl or cycloalkyl group or a C.sub.1 -C.sub.4 alkyl ester or carboxy-protecting ester derivative thereof; or an N-substituted carbamoyl group; and R.sub.1 and R.sub.2 are independently hydrogen or a substituent group, eg. halo, hydroxy, amino, carbamoyl, alkyl, or trifluoromethyl. The antibiotics are useful in a method for treating bacterial infections and can be formulated into pharmaceutical formulations for such use.

REFERENCES:
patent: 3960849 (1976-06-01), Breuer
patent: 4024133 (1977-05-01), Cook et al.
patent: 4258041 (1981-03-01), O'Callaghan et al.
Derwent Abstract No. 32890.

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