(+)-3-substituted-N alkylmorphinans, synthesis and use as antico

Details (+)-3-substituted-N alkylmorphinans, synthesis and use as antico (+)-3-substituted-N alkylmorphinans, synthesis and use as antico

1991-06-05

1993-11-02

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 74, 544287, A61K 31485

Patent

active

052583864

ABSTRACT:
It has been discovered that certain (+)-3-substituted-N-alkylmorphinans are ffective anticonvulsant and neuroprotective agents. Novel compounds having these biological properties are presented in a method of use for preventing, treating or controlling convulsions in mammals having a need for such treatment. The compounds do not lead to dependency, have low toxicity, and provide effective anticonvulsant or neuroprotective treatment with little or no behavioral detriment to the recipient. A number of pharmacological formulations and methods of administering compounds of the invention are suitable for anticonvulsive or neuroprotective treatments.

REFERENCES:
Gates, et al., J. Am. Chem. Soc., vol. 80, pp. 1186-1194 (1958).
Conrow, et al., Steroids, vol. 11, No. 2, pp. 151-164 (1968).
Hori, et al. Chemical Abstracts, vol. 85, 63215z (1976).

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