3-Substituted benzisothiazole, 1,1-dioxides

Details 3-Substituted benzisothiazole, 1,1-dioxides 3-Substituted benzisothiazole, 1,1-dioxides

1977-05-23

1978-08-01

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26029357, 2602948C, 260301, 424263, 424267, 544368, A61K 31495, C07D41704

Patent

active

041043880

ABSTRACT:
3-Substituted benzisothiazole, 1,1-dioxides are provided having the structure ##STR1## wherein R is hydrogen, halogen, lower alkyl, lower alkoxy, or nitro; R.sup.1 is hydrogen, lower alkoxy or halogen with the proviso that R.sup.1 can be lower alkoxy or halogen only when R is lower alkoxy or halogen, respectively; Y is C or N, where Y is C, may represent a double bond, and when Y is N, represents a single bond, A is a single bond or an alkylene group containing from 1 to 4 carbons, and B is hydrogen, hydroxyl, phenyl or phenyl substituted with halogen, lower alkyl, lower alkoxy, or trifluoromethyl, with the proviso that when Y is C, B is phenyl or substituted phenyl, and when Y is N and B is hydrogen, A has at least 1 carbon and when B is hydroxyl, A has at least 2 carbons; and physiologically acceptable acid-addition salts thereof where Y is N. These compounds are useful as antiinflammatory agents.

REFERENCES:
patent: 2751392 (1956-06-01), Grogan et al.
Traverso et al., J. Med. Chem., (1967), vol. 10, pp. 840-844.

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