3-substituted-aminomethyl cephalosporin derivatives

Details 3-substituted-aminomethyl cephalosporin derivatives 3-substituted-aminomethyl cephalosporin derivatives

1984-06-04

1987-07-07

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514201, 514202, 514203, 514204, 514205, 514206, 540 15, 540222, 540224, 540225, 540226, 540227, A61K 31545, C07D50118, C07D50138

Patent

active

046787810

ABSTRACT:
A cephalosporin derivative of the formula I: ##STR1## in which X is S, O, CH.sub.2 or SO, R1 is (optionally-substituted)imidazol-2-yl or one of the C-7 acyl groups known in the cephalosporin art, R2 is hydrogen or methoxy, R3 is carboxy or a biodegradable ester thereof and --R4 is of the formula XII, XIII or XIV: ##STR2## in which R32-R40 inclusive are as defined in the specification; and the salts thereof. Pharmaceutical compositions, methods of manufacture and intermediates are also described.

REFERENCES:
patent: 4386089 (1983-05-01), Konig
patent: 4560749 (1985-12-01), Spry
J. Med. Chem., 1974, 17, 1312-1315 (Nomura et al.).

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