3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, t

Details 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, t 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, t

1980-10-20

1982-02-02

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546257, 546258, C07D40104, A61K 3144

Patent

active

043139515

ABSTRACT:
1-R.sub.1 -3-[amino, cyano, carbamyl, halo, lower-alkylamino, di-(lower-alkyl)amino or lower-acylamino]-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones or pharmaceutically-acceptable acid-addition or cationic salts thereof are useful as cardiotonic agents, where R.sub.1 is hydrogen, lower-alkyl or lower-hydroxyalkyl. 1-R.sub.1 -3-amino-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones are prepared by hydrolyzing the corresponding 3-cyano compounds to produce the corresponding 3-carbamyl compounds and reacting the latter with a reagent capable of converting carbamyl to amino. The 1-R.sub.1 -3-cyano-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones are prepared by reacting (pyridinylmethyl) lower-alkyl ketones with dimethylformamide di-(lower-alkyl) acetal to produce 1-(pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketone and reacting said ketones with N-R.sub.1 -.alpha.-cyanoacetamide to produce the 1-R.sub.1 -3-cyano-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones. Also shown are the conversions: of the 3-cyano compounds to the 3-H compounds; of the 3-H compounds to the 3-halo compounds; of the 3-halo compounds to the 3-[mono-(lower-alkyl)- or di-(lower-alkyl)-amino]compounds; and, of the 3-amino compounds to the 3-lower-acylamino or 3-[mono-(lower-alkyl)- or di-(lower-alkyl)amino] compounds.

REFERENCES:
patent: 4004012 (1977-01-01), Lesher et al.
patent: 4072746 (1978-02-01), Lesher et al.
patent: 4107315 (1978-08-01), Lesher et al.
patent: 4137233 (1979-09-01), Lesher et al.

Affiliated with

Also associated with

Rating

3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, t does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, t will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1821362