3-substituted-6-aryl pyridines

Details 3-substituted-6-aryl pyridines 3-substituted-6-aryl pyridines

2008-03-11

2008-03-11

Morris, Patricia L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S286000, C546S287000, C546S288000, C546S289000, C546S290000, C546S294000, C546S295000, C546S296000, C546S297000, C546S298000, C546S300000, C546S302000, C546S303000, C546S304000, C546S307000, C546S310000, C546S311000, C546S312000, C546S314000, C546S326000, C546S329000, C546S330000, C546S334000, C546S335000, C546S337000, C546S339000, C546S340000

Reexamination Certificate

active

10704364

ABSTRACT:
3-substituted-6-aryl pyridines of Formula I are provided:wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3-substituted-6-aryl pyridines, which are useful as probes for the localization of C5a receptors.

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